In Australia, over half a million people are admitted to hospital every year as a result of injury, and where you live matters.Rural populations have disproportionately higher injury hospitalisation rates (1.5-2.5-fold), higher rates of preventable secondary complications, higher mortality rates (up to fivefold), and higher costs (threefold) than p
Aggressive hemangioma is a rare vertebral lesion in pediatric patients which can present with deteriorating neurological function.It can mimic malignancy on imaging, particularly as it regularly has an extrasosseous soft tissue component.We present a case of a 13-year-old male who presented with a three month history of lower extremity weakness tha
Dominant mutations in a Cu, Zn-superoxide dismutase (SOD1) gene cause a familial form of amyotrophic lateral sclerosis (ALS).While it remains controversial how SOD1 mutations lead to onset and progression of the disease, many in vitro and in vivo studies have supported a gain-of-toxicity mechanism where pathogenic mutations contribute to destabiliz
Urinary extracellular vesicles (uEVs) are released by cells throughout the nephron and contain biomolecules from their cells Tool Box of origin.Although uEV-associated proteins and RNA have been studied in detail, little information exists regarding uEV glycosylation characteristics.Surface glycosylation profiling by flow cytometry and lectin micro
Cellular and animal experiments and computational fluid dynamics (CFD) have revealed that mechanisms of the initiation, growth mat and rupture of a cerebral aneurysm are related to hemodynamics.By direct observation of a cerebral aneurysm during craniotomy, thinning or thickening sites can be found on the aneurysmal wall.The thinning site of a cere